Authors
Sicong (Zone) Liu, Marta R. Durantini, Christopher (CJ) Calabrese, Flor Sanchez, and Dolores Albarracin.
Citation
Liu, S., Durantini, M., Calabrese, C., Sanchez, F., & Albarracín, D. (2024). A systematic review and meta-analysis of strategies to promote vaccination uptake. Nature Human Behaviour. https://doi.org/10.1038/s41562-024-01940-6.
Abstract
Although immunization can dramatically curb the mortality and morbidity associated with vaccine-preventable diseases, vaccination uptake remains suboptimal in many areas of the world. Here, in this meta-analysis, we analysed the results from 88 eligible randomized controlled trials testing interventions to increase vaccination uptake with 1,628,768 participants from 17 countries with variable development levels (for example, Human Development Index ranging from 0.485 to 0.955). We estimated the efficacy of seven intervention strategies including increasing access to vaccination, sending vaccination reminders, providing incentives, supplying information, correcting misinformation, promoting both active and passive motivation and teaching behavioural skills. We showed that the odds of vaccination were 1.5 (95% confidence interval, 1.27 to 1.77) times higher for intervention than control conditions. Among the intervention strategies, using incentives and increasing access were most promising in improving vaccination uptake, with the access strategy being particularly effective in countries with lower incomes and less access to healthcare.
Keywords
vaccination, intervention, systematic review, meta-analysis, intervention strategies.